Abstract

EFFECT OF HARIDRA GHRIT IN HEPATOTOXICITY INDUCED BY ANTITUBERCULOSIS DRUGS - AN ANIMAL STUDY

Tanuja Vyavahare*, Mamata Narwekar, Sanjay Nandedkar and Swagat Patil

Abstract

In recent times, considerable efforts are being made to develop protective agents to be used therapeutically in cases of liver toxicity originating from diverse causes. Drug induced hepatotoxicity has become a major clinical concern with the long-term administration of antituberculosis (Anti-TB) drugs such as rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) specially when used in combination.[1] In the ATT regimen four chemicals are used in combination and the toxicity effect is seen in combination rather than individual use of drugs. Thus, with this reference the anti-tuberculosis drugs may be included in the Gara visha category. Yakrit vikar is also mentioned as a one of the manifestations of Garavishajanya vikriti.[2] In Ashtanga Sangraha Uttarsthan chapter 40/70 various formulations have been quoted for the treatment of ailments caused due to Garavishaktata. Haridra ghrit is one of them.[3] The main content, Haridra i.e Curcuma Longa has antioxidant activity which results in inhibition of lipid peroxidation[4] and shows hepatoprotective property too.[5] The current study was designed to find out Ayurvedic formulation to treat the hepatotoxicity with its in vivo study to screen its effectiveness in albino wistar rats. The pathological obtained results of conspicuous observation have been discussed with scientific reasoning.

Keywords: Haridra Ghrit, Hepatotoxicity, Antituberculosis drugs, Silymarin, lipid peroxidation, oxidative stress.