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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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ICV : 90.8

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	All	Since 2020
Citation	8502	4519
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Abstract

BIOMARKERS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION

Indrakshi Tiwari, *Rahul Vaishnav, Manisha Khandelwal and Piyush Choudhary

Abstract

Important participants in the pathophysiology of stroke include von Willebrand factor (VWF) and intercellular adhesion molecule-1 (ICAM-1). Increased VWF levels are associated with poorer stroke outcomes and indicate endothelial dysfunction. The metalloprotease ADAMTS 13, which degrades VWF, exhibits potential for reducing inflammatory reactions. In the meantime, ICAM-1 affects the prognosis of stroke by promoting immune cell adhesion and is influenced by inflammatory mediators. Comprehending their functions could potentially open doors for therapeutic approaches aimed at managing stroke.

Keywords: The metalloprotease ADAMTS 13, which degrades VWF, exhibits potential for reducing inflammatory reactions.

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