Abstract

DRUG EXCIPIENT INTREACTIONS: OVERVIEW OF DRUG DEGRADATION PATHWAYS

Bhargav Changvadiya, Bhargav Ukawala, M. A. Gupta* and H. D. Karen and C. N. Patel

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Abstract

Drugs are the substance wich are administered as medicines or drug products and they are composed of active substance and excipients.in formulation generation, the interaction of drug excipient is a major concern. Excipients are involved in dosage forms to aid manufacture, administration or absorption. Although considerd pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interaction with drug compounds, which may compromise the action of a medication. excipients are not exquisitely pure. Even for the commonly used excipients, it is necessary to understand the context of their manufacture in order to do identification of potential active pharmaceutical ingredienys interaction with trace components. Chemical interaction lead to degradation of the active ingredient, thereby reducing amount avaliable for theraputic effect. Physical interactions affect rate of dissolution, uniformity of dose or ease of administration.

Keywords: Excipient, Drug, Interaction, Chemical.