Abstract

EXPLORING THE POTENTIAL OF 1-DEOXYNOJIRIMYCIN IN MANAGING PROTEIN METABOLISM AND MARKER ENZYMES IN DIABETIC TILAPIA

Raja Latha and Dr. Gani Sharmila Banu*

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Abstract

Diabetes is a chronic metabolic disorder characterized by high blood glucose levels, which can lead to various complications, including liver and kidney damage. 1-Deoxynojirimycin (DNJ) is a naturally occurring compound found in certain plants and has been shown to have antihyperglycemic properties. The present study investigated the possible protective effect of DNJ on certain biochemical markers in diabetic Tilapia. To induce a transdermal hyperglycemic state in the tilapia, the fish were exposed to water containing 50g/lit of glucose for 14 days. This hyperglycemic state mimics the conditions observed in diabetic individuals and leads to physiological and biochemical alterations. In diabetic tilapia, alterations in blood levels of glucose, urea, uric acid, and creatinine, as well as plasma levels of albumin and albumin/globulin ratio, have been reported. Additionally, the activities of diagnostic marker enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (g-GT), in plasma, liver, and kidney can be affected in diabetic conditions. The administration of DNJ at doses of 10 and 20 mg/kg body weight for 14 days was used to assess its potential protective effect. The study aimed to evaluate whether DNJ could restore the altered biochemical parameters to near-normal levels in diabetic tilapia. The restoration of these parameters would indicate a potential antihyperglycemic effect of DNJ and its ability to alleviate liver and renal damage associated with diabetes in tilapia. In conclusion, the present study aimed to explore the effects of DNJ on biochemical markers in diabetic tilapia. Understanding the protective effects of DNJ could have implications for the development of therapeutic interventions for diabetes-related complications in both aquatic species and humans. Further research is needed to elucidate the underlying mechanisms and validate the safety and efficacy of DNJ in the treatment of diabetes-related conditions.

Keywords: 1-Deoxynojirimycin (DNJ), diagnostic marker enzymes, liver and renal damage, diabetic Tilapia model, therapeutic interventions.