Abstract

PREPARATION AND DEVELOPMENT OF ECONAZOLE USING TRANSFERSOMALS GEL ON ANTIFUNGAL ACTIVITY

Richa Khade*, Brajesh Kumar Arjariya, Sheenam Mansuri, Praveen Bhavsar and Rahim Khan

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Abstract

This study aimed to enhance the penetration of Econazole into the skin through topical application by formulating a transferosomal gel. The research was conducted in three phases: preformulation studies and carrier optimization, preparation and characterization of transferosomal gel, and in vitro evaluation of the delivery system. In the preformulation phase, Econazole exhibited favorable physical and chemical properties, making it suitable for formulation. Transferosomal formulations were developed with nanoscale size, high encapsulation efficiency, and controlled release profiles. Formula F4, demonstrating optimal characteristics, was chosen for incorporation into the gel. Gel formulations displayed desirable viscosity, skincompatible pH, and uniform drug content. Transferosomal gel formulations significantly enhanced the permeation of Econazole compared to plain gel, demonstrating their potential for improved drug delivery. Release kinetics analysis revealed a delayed drug release pattern consistent with diffusion and erosion mechanisms, indicating controlled release behavior. Stability studies indicated that refrigeration preserved the physical stability of transferosomal vesicles, while higher temperatures led to decreased encapsulation efficiency due to lipid bilayer fluidity. In conclusion, transferosomal gel formulations offer a promising strategy for enhancing the delivery of Econazole through the skin. These formulations have the potential to improve therapeutic outcomes in topical applications, providing a valuable option for the treatment of fungal infections.

Keywords: Econazole, Transferosomes, Gel formulation, Topical delivery.