Abstract

PHARMACOLOGICAL ACTIVITY OF BETA VULGARIS L. (BEET ROOT) FOR THE MANAGEMENT OF NEPHROTOXICITY INDUCED BY CYCLOPHOSPHAMIDE

*Anuja Saxena, Dr. Ravi Prakash, Rahim Khan and Ankit Mehra

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Abstract

This study investigates the therapeutic efficacy of Beta Vulgaris L. leaves extract in mitigating Cyclophosphamide-induced nephrotoxicity in experimental rats. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, steroids, amino acids, proteins, and carbohydrates in both methanolic and aqueous extracts. Cyclophosphamide-induced elevation in renal function markers including blood urea nitrogen, creatinine, urea, and uric acid levels was significantly attenuated by Beta Vulgaris L. extract treatment, indicating improved renal function and effective clearance of waste products. Notably, oral administration of the plant extract resulted in a significant reduction in these markers, suggesting its potential therapeutic utility in renal diseases. In conclusion, Beta Vulgaris L. leaves extract demonstrates promising nephroprotective effects against Cyclophosphamide-induced nephrotoxicity, possibly attributed to its rich phytochemical composition. These findings underscore its potential as a natural remedy for renal disorders, warranting further exploration for clinical application.

Keywords: Beta Vulgaris L., Nephrotoxicity. Cyclophosphamide, Renal function markers.