Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF ITRACONAZOLE

Neha, Rashmi Manchanda and Shivani Sharma*

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Abstract

Context: To develop low dose maintenance therapy of Itraconazole. Objetice: To reduce the risk of potential side effects and to improve the patient compliance. Results: Physical appearance of each patch was found to be transparent, uniform and smooth. Thicknesses of all prepared patches were found to be in range of 0.16mm to 0.25mm. Nine formulations (F1- F9) were formulated and evaluated. On the basis of percentage cumulative drug release and folding endurance, F9 formulation was chosen as best formulation. The in vitro drug release profile of optimized formulation was performed in phosphate buffer of PH 7.4. Percent cumulative drug release was found to be 95.42 ± 1.45 at 24 hours. This could be accounted for the slower and control release of drug from transdermal patches.

Keywords: Itraconazole, Transdermal Patch, Thickness, Formulations.