Abstract

A REVIEW ON ADVANCED PARENTERAL DRUG DELIVERY AND MANUFACTURING TECHNOLOGY

Preeti Aneja*, Rajender Guleria, Suyog Garad, Shivali Aneja, Yushmita Thakur, Shilpa Thakur and Palvi Sharma

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Abstract

Parenteral drug delivery refers to the administration of pharmaceuticals directly into the body through non-oral routes, bypassing the gastrointestinal tract. It offers several advantages such as rapid drug absorption, precise dosing, and enhanced bioavailability, making it a critical method for delivering a wide range of therapeutic agents. To ensure safe and effective parenteral drug delivery, the development and utilization of advanced manufacturing technologies are essential. It highlights the importance of manufacturing technology in ensuring the characters, assurance and efficiency of parenteral drug products. Various manufacturing techniques have been employed in the production of parenteral drugs, including formulation development, sterile drug manufacturing, and packaging. Manufacturing technology plays a crucial role in the production of parenteral drug products, as it directly impacts product quality, stability, and patient safety. Key manufacturing considerations include selection and characterization of suitable excipients, optimization of formulation parameters, aseptic processing, and ensuring product sterility throughout the manufacturing process. Moreover, advancements in manufacturing technology leads to upliftment of innovative drug delivery systems, such as prefilled syringes, autoinjectors and implantable devices, which offer improved convenience, patient compliance, and controlled drug release. In order to emphasize the significance of integrating advanced manufacturing technology in the upliftment and production of parenteral dosage form, the need for robust quality control measures, adherence to regulatory guidelines, and continuous process improvement is to meet the ever-increasing demands of the pharmaceutical industry and deliver safe and effective therapies to patients.

Keywords: Drug delivery, Parenteral, Extended release, Packing, Syringes, Carriers.