Abstract

FORMULATION AND EVALUATION OF NYSTATIN NIOSOMAL GEL DRUG DELIVERY SYSTEM

Shish Kumar, *Shivam Kumar, Abhishek Soni and Vaishali Gupta

Abstract

Purpose: Niosomes are becoming more essential in medication administration due to their potential to minimize toxicity and alter pharmacokinetics and bioavailability. Topically applied Niosomes may prolong drug residence duration in the stratum Corneum and epidermis while lowering drug absorption in the blood stream. It can serve as drug storage and delivery systems. The drug release rate and affinity for the drug can be adjusted by changing the vesicular composition or surface features. Desired location Nystatin with a broad spectrum of action that can be used to treat both superficial and systemic infections. Infections caused by fungi. Materials and Procedures: In order to increase low skin penetration while reducing negative Effects Nystatin Niosomes were generated using a Ether injection method in conjunction with topically conventional drug administration. Using a way A Ether injection Method approachwas used to make Nystatin Niosomes utilizing varies ratios of non-ionic surfactant (Span 60) and cholesterol. Size- Spherical shape-Unilamellar, entrapment efficiency, and Drug Content, Viscosity and pH range Antifungal activity test were all examined in the Following Formulations. Were discovered for the Nystatin Niosomes formulations. The size range was discovered to the spherical. Niosomes of Nystatin synthesized with Span 60 at a ratio were found to be promising. Carbopol was added in different concentrations. The prepared gels were tested for a variety of physicochemical properties. Results: The formulations were screened for Physical appearance The gel prepared by test clarity, cooler, homogeneity and present of Evaluation pH- pH after 0th days-6.0,5.9,7.0, pH after 15th days-6.8,6.9,7.0 pH after th days 6.7,6.9,7.0 Rheology test - RPM 0.1-FS-54888 FL-44091 Vesicles size Diameter-2.52-3.42 μm FS 60FL 100 Drug Content- Formulation Code % Drug content-FS-1 94.64,FS-2 93.41,FL-1 95.22,FL-2 91.73 Medicine Entrapment Efficiency- FS 98.70 FL 99.02 Stability Study Entrapment efficiency(%) 5°C refrigeration temperature 52.4,50.1,49.6,49,3- (%) 50°C room Temperature-98.13, 94.94, 92.8,91.8 Anti fungal test Diameter Zone of Inhibition (mm) Aspergillus Niger 26.8,- 36.0, 27.5, 35.1 20.5.

Keywords: Span 60, Cholesterol, Stearic acid, Diethyl ether Triethanolamine.