Abstract

POTENTIAL POLYMER FOR DRUG DELIVERY – CALIXARENE

Thejeswini* and S. Bharath

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Abstract

The article delves into the fascinating world of calixarenes, cyclic oligomers derived from phenol-formaldehyde chemistry. It traces the historical development of calixarenes from Adolph von Baeyer's initial experiments to modern-day research by scientists like John Munch and Gutsche. The synthesis methods, physical properties, and applications of calixarenes are thoroughly explored. The synthesis of calixarenes involves complex chemical processes, with variations in methods leading to different properties. Separation and purification techniques are crucial due to the compounds' low solubility in organic solvents. The physical properties of calixarenes, such as high melting points and unique IR spectra, distinguish them from their acyclic counterparts. Calixarenes exhibit remarkable potential in various fields, particularly in pharmaceutical sciences. Their ability to form distinct morphological aggregates with drugs and biomolecules makes them promising candidates for drug delivery systems. Functionalized calixarene molecules can self-assemble into organic nanomaterials, offering innovative solutions for drug solubilization and encapsulation. The study also discusses the application of calixarenes in enhancing the solubility and bioavailability of medications with low water solubility. Specifically, the article highlights the potential of calixarenes in treating tuberculosis by enhancing solubility through hydrophilic modifications, paving the way for novel therapeutic approaches. Overall, the article provides a comprehensive overview of calixarenes, from their synthesis and physical properties to their diverse applications in drug delivery and pharmaceutical sciences.

Keywords: Polymer, calixarene, physicochemical properties, drug delivery, drug carrier.