Abstract

NANOSUSPENSION- A REVIEW

Zaynab Nasikkar* and Komal Pawar

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Abstract

Poorly soluble drugs are the drugs which have major problems related to their solubility profile. These drugs have low bioavailability as they belong to BCS class II and class IV of biopharmaceutical classification. The problem is more in cases of drugs such as Ketoconazole, Carbamazepine, Itraconazole, etc. as these drugs have low solubility in aqueous and non-aqueous media One of the major problems associated with poorly soluble drugs is very low bioavailability. To overcome such problems of bioavailability formulation of Nanosuspension is a promising approach and a best alternative. Nanosuspension consists of a poorly water soluble drug suspended in form of dispersion. Nanosuspension is applicable to all drugs which have low solubility problems as it alters the pharmacokinetic profile of the drug. This formulation also improves drug safety profile and efficacy. This review article describes Nanosuspension in details with methods of classification, Preparation, application and characterization.

Keywords: Solubility enhancement, Low bioavilability, Nanosuspension technique, Target specific, Drug delivery, Dissolution.