Abstract

CELL FREE DNA (CFDNA) AS BIOMARKER IN STROKE

Indrakshi Tiwari, Rahul Vaishnav*, Rajveer Singh Panwar, Nirmal Sodha, Piyush Choudhary and Parv Gandhi

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Abstract

It highlights the presence of cfDNA across various bodily fluids and its role in inflammation, particularly in the context of stroke-induced tissue injury. The abstract emphasizes recent advancements in quantifying cfDNA and its specificity in distinguishing stroke from its mimics, as well as differentiating between ischemic and hemorrhagic stroke. Kinetic studies reveal the temporal pattern of cfDNA release post-stroke, with notable associations between elevated cfDNA levels and early hospital admission, stroke severity, and response to therapy. Furthermore, correlations with other biomarkers such as neuronspecific enolase, S100 protein, and C-reactive protein underscore the multifaceted utility of cfDNA in stroke diagnosis, subtype classification, and prognostic evaluation. The abstract concludes by advocating for further exploration of cfDNA as a promising tool in clinical stroke management.

Keywords: Cell-free DNA, Tissue injury, Stroke, Inflammation.