Abstract

NEUROTHERAPEUTIC COMPARISON OF ARIPIPRAZOLE AND ETHANOLIC EXTRACT OF FRAGARIA ANANASSA ON CEREBRUM AND AMYGDALA OF METHAMPHETAMINE INTOXICATED MALE WISTAR RATS

*Odi C. F. and Ezejindu D. N.

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Abstract

The obvious need for other effective therapeutic medication for methamphetamine induced cerebral and amygdala toxicity have warranted this reseach. Fragaria ananassa, extracted ethanolically. current study looked at the neurotherapeutic comparison of the ethanolic extract of Fragaria ananassa on cerebrum and amygdale of methamphetamine intoxicated wistar rats. The rats were used in 8 groups. Oxidative stress markers were analysed, neurobehavioural tests were carried out, histological examination was done. SPSS version 20.0 was used to analyze the data, with a 0.05 considered significant. Group A was the control group and B received 100mg/kg of meth. Group C received received 200mg/kg of ethanolic extracts of strawberry. Group D, E, F 100mg/kg of meth and 100mg/kg of ethanolic extract of strawberry and finally 100mg/kg of meth a d trested with 200mg/kg of ethanolic extract of strawberry a d 10mg/kg of aripiprazole respectively. Correlation of the initial weight and the final weight shows an obvious increase in weight of the rats especially the control group (A) and the F, G group. The histoarchitecture showed marked degeration of neuronal cells in group B which received methamphetamine alone but knew further improvement in groups that were subsequently treated with the extract. The study further demonstrates that oxidative stress (SOD, MDA, CAT) were not significantly altered also as long as the ethanolic extracts of strawberry were administered alongside the ingested methampohetamine in line with other hypotheses.

Keywords: Methamphetamine, Cerebrum, Amygdala, Wistar Rats.