Abstract

THE ROLE AND PHARMACOLOGICAL ACTION OF ANTIMALARIAL DRUGS IN ELIMINATING MALARIA

Ravina Naik*, Navditya, Vishal Verma, Yukta Sharma and Anamika

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Abstract

Transmission of malaria is decreased by effective antimalarial medication treatment. Even if the benefits are more pronounced in low-transmission areas where a larger percentage of the infectious reservoir is symptomatic and receives anti-malarial treatment, this alone can lower the incidence and prevalence of malaria. therapy. When it comes to falciparum malaria, when gametocytogenesis is delayed, effective therapy has a higher impact on transmission than it does on other human malarias, where peak asexual parasite density and gametocytemia coincide. Artemisinin’s and 8-aminoquinolines are the only drugs that can target mature Plasmodium falciparum gametocytes, which are more resistant to drugs. Whether primaquine should be added to artemisinin combination therapy for the treatment of falciparum malaria in order to further minimize the transmissibility of the treated illness is now the most important operational question. The use of primaquine in radical therapy has a crucial part in the elimination of ovale and vivax malaria. To guide both individual and group treatment decisions, more research is required on the safety of primaquine when it is administered without first checking for G6PD deficiency. One of the biggest causes of illness in the tropics is still malaria, which primarily affects children under the age of five. Plasmodium falciparum, P. vivax, and P. ovale are the causative agents of the most common and deadly form of malaria. Malaria is treated and prevented with chloroquine. Additionally, it is used to treat liver infections brought on by extraintestinal amebiasis. Chloroquine is a member of the class of medications known as antimalarials. It functions by treating or preventing malaria, a disease of the red blood cells contracted through mosquito bites.

Keywords: Antimalarial, Malaria, Parasite, Plasmodium falciparum, Ovale, Vivax.