Abstract

IMPLANTABLE DRUG DELIVERY SYSTEM: AN INNOVATIVE APPROACH

Tithee Patel*, Nagesh Modi, Mona A Gupta* and Dr. C. N. Patel

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Abstract

This paper provides an in-depth discussion on the manufacturing methods and therapeutic applications of implantable drug delivery devices. Various manufacturing techniques such as hot melt extrusion, solvent casting, compression, injection molding, and 3D printing are explored in detail. The therapeutic applications of implantable drug delivery systems in ocular implants, dental implants, cancer therapy, infectious diseases, contraceptive implants, and pain management are also examined, with examples of devices and drugs provided for each application. Additionally, the paper delves into the mechanisms of drug release from implantable systems, including diffusion-controlled release, chemically controlled release, bioerosion, swelling-controlled release, and osmotically controlled release. The advantages of implantable drug delivery systems in improving patient compliance and efficiency are highlighted, along with the limitations such as the risk of adverse reactions and the need for surgical intervention for implantation.

Keywords: Implantable drug delivery, Osmotic pump, controlled release, Hot melt extrusion, cancer therapy, 3D printing, Application.