Abstract

SYNTHESIS, CHARACTERISATION OF ETHYL 7-METHYL-2-(4- NITROPHENYL)-5- PHENYL-5H-[1, 3, 4] THIADIAZOLO [3, 2-A] PYRIMIDINE-6-CARBOXYLATE PROMOTED BY BRONSTD ACID

Konisi Saikiran and Dr. N. Krishnarao*

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Abstract

This investigation is an efficient and versatile synthesis of ethyl 7- methyl-2-(4-nitrophenyl)-5- phenyl-5H-[1, 3, 4] thiadiazolo [3,2-a] pyrimidine-6-carboxylate promoted by Bronstd acid. These derivatives can be obtained from 5-(4-nitrophenyl)-1, 3, 4-thiadiazol-2-amine with substituted aromatic aldehyde and ethyacetoacetae in the presence of Bronstd acid such as Methanesulphonic acid at reflux. The compound 5-(4-nitrophenyl)-1, 3, 4-thiadiazol-2-amine prepared by the mixture 4- nitrobenzoic acid with thiosemicarbazide in protic acid in DMF at 700C.The titled derivatives can be evaluated by spectroscopic data such as IR, 1HNMR, 13CNMR and LCMS and also the structure of the compounds determined by elemental analysis. In addition to the study of the biological properties.

Keywords: 4-nitrobenzoicacid, thiosemicarbazide, 5-(4- nitrophenyl)-1,3,4-thiadiazol-2-amine, aryl aldehyde, MSA, ethyl 7- methyl-2-(4-nitrophenyl)-5- phenyl-5H-[1, 3, 4] thiadiazolo [3,2-a] pyrimidine-6-carboxylate.