Abstract

DEVELOPMENT AND VALIDATION OF A RELIABLE SPECTROPHOTOMETRIC METHOD FOR FAVIPIRAVIR ANALYSIS IN BULK AND TABLET DOSAGE FORM

Harshitha M.*, Sowmya H. G. and Naveen Kumar G. S.

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Abstract

Simple, precise and accurate zero order derivative spectroscopic method has been developed and validated for the estimation of favipiravir in bulk and pharmaceutical dosage form. The drug shows maximum absorption (λ max) at 361nm in 0.1N NaOH and obeys Beer’s law in the concentration range of 2-12μg/ml. The linearity study was carried out and regression coefficient was found to be 0.9988 and it has showed good linearity, precision during this concentration range. The % recovery was found to be 99.16 -101.8. The LOD and LOQ were found to be 0.137 and 0.416μg/ml. The % relative standard deviation were found to be less than 2. According to ICH guidelines the technique has been validated for linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ. The developed and validated method can be successfully applied for routine quantification of favipiravir in bulk and pharmaceutical dosage form.

Keywords: Favipiravir, zero order derivative spectroscopy, validation, pharmaceutical formulations.