Abstract

DEVELOPMENT AND EVALUATION OF POLYHERBAL ANTIDIABETIC TABLET

Nikita U. Dhake*, Mona Y. Agrawal, Dr. Yogesh P. Agrawal, Rajashri R. Dhonnar and Akash S. Nimbone

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Abstract

The main objective of the project is to formulate and evaluate polyherbal antidiabetic tablet. Polyherbal antidiabetic formulation consist of four herbs viz., Syzygium cumini (leaves), Aloe barbadensis (whole leaf), Tinospora cordifolia (stem) and Triphala churna. The granules were prepared by wet granulation technique. The granules prepared out from the extract of above four herbs were investigated for preliminary studies like bulk density, tapped density, hausners ratio, compressibility index and angle of repose. Three different batches of tablet were prepared (F1, F2 and F3) using direct compression method. The present study deals with the evaluation of formulated tablet (Hardness, Thickness, Disintegration time, Friability, Loss on drying and weight variation). Stability studies were carried out to determine the stability The antidiabetic potential of formulation was determined by inhibition of carbohydrate digestive enzyme i.e. α– amylase enzyme and α-glucosidase enzyme.

Keywords: The granules were prepared by wet granulation technique.