Abstract

A COMPREHENSIVE REVIEW ON QUINOLINE AND ITS DERIVATIVE INCLUDING THEIR SYNTHESIS AND PHARMACOLOGICAL APPLICATIONS

Aishwarya V. Lichade*, Dinesh P. Kawade, Vaishnavi S. Bhure, Bhagyashri S. Patil, Shubhangi H. Bhowate, Pranita I. Rathod and Shweta V. Rane

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Abstract

Numerous heterocyclic analogues were assessed for their various biological actions, which prompted a thorough investigation and study of these substances. Among these, the quinoline a nucleus is a vital component found in a wide range of artificially produced drugs with a range of therapeutic uses. It can be found in several naturally occurring compounds with a variety of biological functions, such as antiinflammatory, anti-microbial, anti-cancer, and anti-malarial qualities, as well as pharmacologically active substances (Cinchona Alkaloids). Many methods, such as catalyst-based synthesis, microwave aid, and conventional synthesis, can be used to synthesize quinoline and its derivatives. Quinolone-4-carboxylate derivatives were prepared in a microwave with pyruvic acid, anilines, and benzaldehyde among the additional chemicals. Our goal is to produce quinoline derivatives that are more potent, less toxic, easier to synthesize ecologically, and require fewer hours of work.

Keywords: Bioorganic, cincophen acid, Doebner reaction, Quinoline, ecological synthesis.