Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF ACALYPHA FRUTICOSA EXTRACT TABLETS DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR CONTROLLING DIABETES

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

.

Abstract

Prevention of various diseases using natural compound has been of interest for many decades. Floral diversity has been widely investigated for possible protective and preventive properties and various plant-based medicines have been introduced in the recent times. Diabetes is a serious health concern in many countries with high blood glucose, obesity, and multiple organ failures in late stages. Treating diabetes with effective drugs is still a challenging issue since most of the available diabetic drugs are not effective in combating diabetes, especially in secondary disease complications like obesity retinopathy, and nephropathy associated diabetes. Hence search for effective anti-diabetic medication, especially from natural sources is mandatory with no adverse side effects. The Acalypha Fruticosa is plant widely distributed in Yemen. It is used for anti-diabetic medication, antioxidant, dyspepsia, a cure for stomachache, dermatitis, anti-aging effects, and cytotoxicity. It has been used as a venom antidote and prevent damage to cellular macromolecules, antimutagens and anticarcinogens. In the present study the Acalypha Fruticosa was formulated as tablets and evaluate for organoleptic properties using tests as, weight variation, hardness, disintegration time, in-vitro dissolution and other evaluation parameters. It was concluded that among the all formulations of Acalypha Fruticosa extract tablets the F1 was found to be as an optimized tablets according to drug release percentage 75.9% within 30 minutes and 89.5% within 60 minutes, so the F1 was the best formulation of Acalypha Fruticosa medicinal herbs extract tablets delivery system as an advanced phytotherapy approach for controlling diabetes.

Keywords: Acalypha Fruticosa, Extract, Tablets, Medicinal herbs, Antidiabetic, Phytotherapy.