Abstract

RECENT INNOVATIONS OF NOVEL DRUG DELIVERY SYSTEMS FOR FORMULATION, DEVELOPMENT AND EVALUATION OF PANDANUS ODORATISSIMUS EXTRACT CAPSULES AS NATURACEUTICAL FOR BREAST CANCER

Dr. Mahmoud Mahyoob Alburyhi* and Dr. Amina El-Shaibany

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Abstract

Cancer is a large group of diseases that can start in almost any organ or tissue of the body when abnormal cells grow uncontrollably, go beyond their usual boundaries to invade adjoining parts of the body and/or spread to other organs. Breast cancer is the most common cancer worldwide and leading cause of cancer death among women disproportionately affecting individuals in low- and middle-income countries. Use of medicinal plants and their products are almost doubled over the last decade in developing countries. The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit the development of cancer either by impeding DNA damage, which leads to malignancy or by reversing or blocking the division of premalignant cells with DNA damage. The success of using chemopreventive agents for protecting the high-risk populations from cancer indicates that the strategy is rational and promising. However, use of natural compounds for cancer prevention may mitigate associated toxicity. Pandanus Odoratissimus has antiviral, antiallergy, antiplatelet, anti-inflammatory, antioxidant, and anticancer action. The Pandanus Odoratissimus is medicinal plant widely distributed in Yemen. The flowers of Pandanus Odoratissimus were collected from Taiz, Yemen. The objective of the present study was to prepare the extract of Pandanus Odoratissimus flowers as capsules delivery system which used for breast cancer. It was concluded that among the all formulations the formulation F1 is the best results of Pandanus Odoratissimus extract medicinal herbs capsules delivery system as an advanced phytotherapy approach for breast cancer according to the drug release was found to be 98.7% within 60 minutes.

Keywords: Pandanus Odoratissimus, Extract, Capsules, Medicinal herbs, Breast cancer, Anticancer, Phytotherapy.