Abstract

ETHOSOMES AS AMPHIPHILIC VESICLES FOR MODIFIED DRUG DIFFUSION TO SKIN

Bhanu Pratap*, Shamim Khan and Shadab Ali

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Abstract

Transdermal drug delivery system was 1st introduced more than 20 years ago. This system is a type of traditional drug delivery system in which drug under goes to the systemic circulation through the protective barrier i.e. skin. Skin is a major target and barrier for topical and transdermal drug delivery, but the low diffusion rate across the stratum corneum is a major hindrance. Various methods have been conducted to improve drug permeation rate temporarily via skin, such as by help of elastic vesicles or skin enhancers. Vesicular systems like ethosomes, are controversial methods for transdermal drug delivery due to their higher penetration rate through the skin due to their ethanolic content. Herbal Ethosomes are composed of phospholipids, API, Herbal ingredient, alcohol, polyglycol and water. The purpose of this article reviews is to focus on various aspects of Herbal ethosomes, including their mechanism of penetration, preparation, advantages, characterization, composition, preparation, and application, highlighting the potential for novel improved therapies.

Keywords: Anti-fungal, Topical route, Ethosomes, Skin.