Abstract

EVALUATION OF WOUND HEALING ACTIVITY OF SOODAN (CAMPHOR) POWDER AND OINTMENT IN WISTAR ALBINO RATS

Vijayarajah Thanushiyan* and Dr. Bamini Mithurendran

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Abstract

Background: One of the most important biological processes in tissue regeneration and repair is wound healing. Numerous topical drugs are used to promote wound healing. In any case, the emergence of bacterial resistance and expensive calls into question their effectiveness. The purpose of this study was to assess the healing effectiveness of purified soodan powder and ointment applied to excised wounds in Wistar albino rats. Methods: Healthy albino rats weighing between 150 and 200 grams were used in the study. Six rats each were placed in the following groups: Untreated group, Ointment base group, Neosporin powder group, 10% w/w Neosporin ointment group, purified soodan powder group, 10% w/w purified soodan ointment group. The rats' dorsolateral portion of the thorax was lacerated using a 120 mm2 wound. Size of the wound was measured and bandaged every two days until the fourteenth day. The percentage change in the initial size of the wound over a range of days was used to compute the percentage of the wound contracting. Results: Significant difference in wound circumference between untreated and Neosporin powder group (p=0.029), untreated and purified soodan powder group (p= 0.044), untreated and 10% w/w Neosporin ointment group (p=0.000), untreated and 10% w/w purified soodan ointment group (p=0.003), untreated and emulsifying ointment base group (p=0.252) with the mean values of 3.500,3.333,7.667,4.333,2.500 respectively. Conclusion: It is concluded that 10% w/w purified soodan ointment has a highly substantial wound healing impact in excised wounds, while purified soodan powder is moderately significant.

Keywords: Camphor Ointment, Dosage, Pharmacological activity, Unit Healing Time, Wound Contraction Rate.