Abstract

SYNTHESIS AND BIOEVLUATION OF N-(5-(4-(METHYLSULFONYL) BENZYL)-1, 3, 4-THIADIAZOL-2-YL)-1-PHENYLMETHANIMINE PROMOTED BY PTSA

M. Maruthi, Dr. Krishnarao, Dr. S. Srinivasarao*

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Abstract

Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. The Synthesis of N-(5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-yl)-1- phenylmethanimine promoted by PTSA which can be obtained 5-(4- (methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-amine with aromatic aldehyde in ethanol and acetic acid at reflux. The compound 5-(4- (methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-amine can be prepared from 2-(4-(methylsulfonyl) phenyl) acetic acid and thiosemicarbazide in con H2SO4 in DMF as solvent at 70-800C. All the titled analogous were evaluated by the advanced spectroscopic analysis such as 1HNMR, 13CNMR and LCMS and structural determination of titled analogous were calculated by elemental analysis. In addition to the newly synthesized compounds were examined by their anti-microbial activity.

Keywords: 5-(4-(methylsulfonyl) benzyl)-1, thiosemicarbazide, substituted aryl aldehyde 1,3,4-thiadiazol-2-amine,N-(5-(4-(methylsulfonyl)benzyl)-1,3,4-thiadiazol-2-yl)-1- phenylmethanimine,PTSA, antimicrobial activity.