Abstract

FORMULATION AND EVALUATION OF PHYTOSOMES

Rishu Singh, Umesh Chandra and Sanjay Kumar Kushwaha*

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Abstract

Since ancient times the therapeutic uses of traditional medicines and phytome dicines have proved very popular for health maintenance by various means. During the last century chemical and pharmacological studies have been performed on many plant extracts in order to investigate their chemical composition and confirm their therapeutic usefulness.[1] Over the past several years, great advances 1 Phytosome technology emerged in 1989.[2] Water-soluble phytoconstituents (mainly polyphenols) can be converted into a lipid-compatible molecular complex known as phytosome. A phytosome is generally more bioavailable. than a simple herbal extract due to its enhanced capacity to cross the lipid-rich biomembranes and to reach systemic CIRCULATION 3 Phytosome is obtained by reacting of soy phospholipids with the selected botanical derivatives in an opportune solvent. On the basis of their physical-chemical and spectroscopic characteristics, these complexes can be considered novel entities.[4] Phytosomes (P) increases absorption of polar phytoconstituents orally which are lipid insoluble in nature and topically shows an increase in bioavailability whichresults in greater therapeutic benefit. When the rate of absorption rate of an active constituent is increased, the dose required will be reduced.[5]

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