Abstract

PURIFICATION AND IMPURITY CONTROL IN APIS

Harshad Harishchandra Ubale*, Shubham Gorakh Kshirsagar, Ritika Dipak Vagare, Bhagyashri Balaso Shinde

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Abstract

A majority spectroscopic and chromatographic method can be performed alone or by the conjunction with the help of method to determine the contaminants. Impurities can be found and characterised using a variety of techniques like atomic absorption spectroscopy (AAS), HPLC, HPTLC. Traditional HPLC in particular form of liquid chromatography, has been thoughtfully utilised throughout the field of impurity profiling. Opportunities for continuous separation based on polymer membrane wettability are created by the ongoing processing of pharmaceuticals. In-line liquid-liquid extraction is made possible by the dual utilization of hydrophobic and hydrophilic membranes in the synthesis of four crucial APIs. Phase separation of aqueous–organic reaction streams depends on a secondary membrane with opposing wetting properties. Many purification techniques can be used to purify pharmaceutical drugs at all scales, addressing some of the more difficult problems associated with drug purification. Pharmaceutical medications method such as single-use manufacture, chromatography, sterile sampling, ultrafiltration, process development, and sterile filtration.

Keywords: In-line liquid-liquid extraction is made possible by the dual utilization of hydrophobic and hydrophilic membranes in the synthesis of four crucial APIs.