Abstract

A SHORT PREFORMULATION STUDY OF PURE METFORMIN HCL

S. Naveen*, K. Nirmal and B. Jayanthi

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Abstract

Metformin HCl is a first line drug of choice for the treatment of type II diabetes which acts by decreasing hepatic glucose output and peripheral insulin resistance. It can be given to obese patients with overweight having normal kidney function. The overall objective of preformulation testing is to generate information useful to the formulator in developing stable and bioavailable dosage forms, to determine kinetics and stability of drug and to establish drug excipients compatibility. Preformulation study was done and all results were in the range of prescribed in Indian Pharmacopoeia, so the drug was found to be of standard prescribed purity and quality Infrared spectra of the drug reveal that there is no significant interaction between drug polymers. The primary objective of this DSC study was to identify a stable storage condition for Metformin HCL in solid state and identification of compatible. A solution of 10μg/mL of Metformin HCl was scanned in the range of 200 to 400 nm. The drug exhibited the λmax at 234 nm in distilled water has good reproducibility graph. UV method was used for Estimation of Metformin HCl and absorbance values were measured using an ultraviolet–visible (UV-VIS) spectrophotometer at λmax 234 nm.[1]

Keywords: MetforminHCl, Preformulation and Type II diabetes.