Abstract

DEVELOPMENT AND EVALUATION OF HARD GELATINE CAPSULE OF ACECLOFENAC DRUG

Bhukya Nageswar Rao*, K. Sai Nikhil, M. Navya, K. Manisha, D. Pavani, B. Yamini,

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Abstract

The oral route is the one most frequently used for drug administration. Oral dosage forms are usually intended for systemic effects resulting from drug absorption through the various epithelia and mucosa of the gastrointestinal tract. Capsules are solid dosage forms containing drug and usually appropriate filler(s), enclosed in a hard or soft gelatin shell. Aceclofenac, Empty hard gelatin capsules, PEG 4000 and all other materials were obtained through commercial sources. Aceclofenac granules were prepared by wet granulation method. Specified quantity of Aceclofenac, micro crystalline cellulose and PEG 4000 will be weighed and mixed uniformly. Required quantity of alcohol drop wise incorporated to the blend. Wet granules will be passed through sieve #10 & air dried for 15 minutes. The dried granules will then be passed through sieve #22. Required quantity of magnesium stearate & talc were added to the granules. The prepared granules were then added to the Size #3 empty hard gelatine capsule. The formulation of granules of Aceclofenac is shown in Table 2. Aceclofenac was planned to formulate as an immediate release system. The prepared granules were evaluated for percentage yield, angle of repose, bulk density, tapped density, Hausner’s ratio and Carr’s index. The hard gelatin capsule containing granules of aceclofenac were also evaluated for disintegration time, drug content and in-vitro drug release. Stability study shows that there was no significant change in disintegration time, drug content and in-vitro drug release of the formulation. Thus, formulation was considered optimized formulation for immediate release of Aceclofenac.

Keywords: Aceclofenac, Hard Gelatin Capsules, PEG 4000.