Abstract

A COMPREHENSIVE REVIEW OF PROTON PUMP INHIBITORS IN MANAGEMENT OF GASTROINTESTINAL DISORDERS

Kuldeep Kumar, Ritesh Kumar, Amanpreet Kaur* and Naresh Singh Gill

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Abstract

PPIs are among the most often given medications for infants and kids, and their use has dramatically increased over the past few decades. PPIs have been considered safe medications and are evidently successful when used as prescribed, however there is mounting evidence that they may have adverse effects. However, it is evident that many of these are also pertinent to pediatrics, primarily based on adult evidence. PPI use may have an impact on the composition and function of the gastrointestinal microbiota, reduce defences against pathogens, which increases the risk of infections, impede the absorption of minerals and vitamins, increasing the risk of certain deficiencies and bone fractures, and interfere with the digestion of proteins, increasing the risk of sensitization to allergens, the development of allergic diseases, and eosinophilic esophagitis. From adult data, a weak and unproven connection has also been inferred with pancreatic, liver, and stomach cancer. Overall, there is inconsistent and often weak data supporting these harmful effects. All things considered, there is considerable potential advantage to the selective use of PPIs for reasons with strong evidence, although babies and children should take them with greater caution. The worries about possible side effects linked to their use should be known by pediatricians.

Keywords: Proton pump inhibitors, Indications, Antioxidant potential, Gastrointestinal disorders, Gastric acid.