Abstract

A RESEARCH ON FORMULATION AND EVALUATION OF DICLOFENAC SODIUM GEL BY USING CARBOPOL 940

Bhakti Todmal*

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Abstract

The present investigation is concerned with formulation and evaluation of Transdermal gels of Diclofenac sodium, anti-inflammatory drug, to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. Three formulations were developed with varying concentrations of polymers of Carbopol 940. The best in-vitro drug release profile was achieved with the formulation F1 containing 1 gm of Diclofenac sodium with desired therapeutic concentration which contains the drug and Carbopol 940 in the ratio of 1:2. The present research has been undertaken with the aim to develop a topical gel of diclofenac sodium gel (DS) 1%, evaluation of its physico chemical characteristics. The main objective of this research paper is to prepare and evaluate 1% polymer containing transdermal gel of Diclofenac Sodium. The gel was prepared and evaluated for pH, Spreadability, Consistancy, Homogeneity, Drug Content, Extudibility. The carbopol is high molecular weight water soluble homo polymer which posses high viscocity in low concentrations, transparency, and film Forming properties these are useful for gel formation. The percentage of drug release was 97.68%. The present study suggests that the Diclofenac sodium effectively act as in vitro anti-inflammatory activity.

Keywords: Transdermal gel, Viscosity, In-vitro drug release, Topical Drug Delivery, Anti-inflammatory, Water Soluble Polymer, Carbopol940.