Abstract

A PERSPECTIVE ON SYNTHESIS OF NOVEL BENZOTHIAZOLE DERIVATIVES BY USING MICROWAVE-ASSISTED & CONVENTIONAL TECHNIQUES

Aniqua T. S. Sheikh*, D. P. Kawade, Ashwin U. Rahangdale and Anirudh S. Mishra

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Abstract

Benzothiazole refers to a pair of rings that include the heterocycles thiazole and benzene combined. Benzothiazole-based compounds have been developed for use as anti-tubercular, anti-diabetic, anti-cancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anti-convulsant, anti-malarial, and other medicinal agents throughout the entire field of medicinal chemistry. This work offers a logical and comprehensive assessment of these advancements. This work focuses on utilizing a one-pot, three-component microwave aided approach to synthesize novel substitutions of ethyl 2-methyl4- (pyridine-2-yl)-4H-benzo [4,5] thiazolo [3,2-a]pyrimidine-3- carboxylate. Benzothiazole derivatives with polyfunctionalized triheterocyclic structure have recently been synthesized and described by means of several spectroscopic methods, such as single crystal X-ray analysis, FT-IR, 1H NMR, and 13C NMR, in addition to elemental analysis. Each final scaffold's antibacterial and antitubercular efficacy against Mycobacterium tuberculosis H37RV was tested.

Keywords: Benzothiazole, antibacterial, antifungal, microwave-assisted, solvent-free condition, etc.