Abstract

THE EMERGING DEVELOPMENT OF POLYCYSTIC OVARIAN SYNDROME

Priya Chandel*, Vaishali and Manju Jakhar

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Abstract

Polycystic ovarian syndrome (PCOS) is a complex illness, which is characterised by elevated testosterone levels, irregular menstruation cycle and tiny cysts on one or both polycystis ovaries. PCOS is characterized by hyperandrogenism, hyperinsulinemia, and alopecia, which are hallmarks of PCOS. The genetic etiology of the syndrome is unknown. Several genetic studies and pharmacological studies involving NK3R antagonists encourage similarly investigate the neuroendocrine aspects of the condition. A genome-wide methylation study revealed changes in DNA and gene expression in pathways such as type 1 diabetes mellitus pathway, p53 signaling pathway and NOD. The multiple combination drug designs may be helpful to treat PCOS, and the combination of sex steroids and nitric oxide (NOD) inhibitors may be useful to treat this condition.

Keywords: PCOD, Reproductive disorder, Cysts, Infertility.