Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VALSARTAN TABLET

Selvi A.*, Aravind G., Ganeshraja R., Guruprasad S. and Jayaprakash M.

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Abstract

The immediate release tablet of antihypertensive drug valsartan were prepared evaluate to increase solubility and bioavability. Valsartan is an Angiotension II type I receptor antagonist indicated were prepared by direct compression method. Valsartan tablets were formulated by using microcrystalline cellulose, potato starch, acacia, magnesium stearate and sodium lauryl sulphate. The prepared valsartan immediate release tablets were evaluate for various parameters like weight variation, hardness friability, thickness, disintegration time, dissolution studies and assay. The blend was examined for the pre –compression and post compression parameter. The value of pre-compression parameter evaluates were within prescribed limit and indicates good flow property. All the post compression parameter are evaluated were prescribed limits and results were within IP acceptable limits. Based on the disintegration time and dissolution studies formulation F1 and F5 were found to be optimize and showed a disintegration time of 52 sec respectively.

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