Abstract

STUDY ON THE EFFECT OF TERMINALIA CHEBULA ON ALUMINIUM CHLORIDE INDUCED ALZHEIMER’S DISEASE IN CARASSIUS AURATUS

*Deepa P., Adithya Murali C. K., Nishida, Sneha John, Sreelakshmi M. and Nasreena A. T.

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Abstract

Terminalia chebula extract is well known for its neuroprotective activity. The plant has been studied for its potential therapeutic effects in various disease conditions like depression, cognitive dysfunction, arthritis pain etc. To study the neuroprotective effect of Terminalia chebula extract on Aluminium chloride-induced neurotoxicity in gold fish. Gold fish behavior was assessed in terms of height of the fish in the tank, light /dark test, T-maze and color preference test. The fish were divided in to 4 groups, each group containing 6 fish and neurotoxicity was induced with aluminium chloride in goldfish. The behavioral assessment was carried out. Compared to the control group, the moment decreased throughout the duration of Aluminium chloride treated. Movement was restored up on treatment with drug. When fish are exposed to Aluminium chloride, their mobility is confined to the upper part of the tank. Conversely, when treated with Terminalia chebula extract their movement gradually returns to normal. Under normal conditions, goldfish tended to frequent the yellow area of the tank, while largely ignoring the red region. However, when exposed to Aluminium chloride, they showed a preference for the red zone. Following treatment with Terminalia chebula extract, most fish returned to visiting the yellow region instead of the red. Gold fish have strong preference for the dark zone. The treatment with Aluminium chloride causes goldfish motility was restricted to the dark zone. But terminalia chebula treatment restored mobility.

Keywords: Neurotoxicity, Terminalia chebula extract, Aluminium chloride, Carassius auratus.