Abstract

EVALUATION OF ANTIPARKINSONS ACTIVITY OF RICINUS COMMUNIS OIL BY USING PARAQUAT INDUCED CARASSIUS AURATUS

Deepa P.*, Anagha P. P., Fathimathu Zahra, Shahanas Fathima V. V., Shahitha Afreen and Sona Fathima S.

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Abstract

Ricinus communis oil also known as Castor oil is known for its various medicinal properties like antioxidant, anti inflammatory and central analgesics. The phytoconstituents present in the castor oil responsible for the Neuroprotective action in CNS disorders like Parkinson's disease. The antioxidant property of Castor oil in paraquat dichloride induced Carassius auratus in Parkinson's disease is studied. Carassius auratus is known as Gold fish. The Gold fish obtained were divided into 4 groups with 6 fish each. Neurotoxicity was induced in gold fish by paraquat dichloride for 4 days. One of the group is treated with standard drug, one group is drug treated, one is control group and other is paraquat induced. In comparison to control group the movement is reduced during the course of paraquat treatment. They regained it with treatment with RC oil. Paraquat treatment restricted the movement of fish from moving to dark zone. When fishes treated with paraquat dichloride their mobility is restricted to upper portion of tank, however when they are treated with RC oil their movement is gradually restored. The standard, control, drug treated showed aggressive, response towards the mirror test, while paraquat treated doesn't show any interaction or response to the mirror test. The fish in standard and drug treated was showed positive response towards shoal cohesion, while paraquat treated doesn't showed shoal cohesion.

Keywords: Ricinus communis, Neuroprotective, Carassius auratus, Paraquat dichloride.