Abstract

EFFICIENT PROTOCOL FOR THE SYNTHESIS OF BENZODIAZOPINES IN ATTENDANCE OF SIO2@MSA AS HETEROGENEOUS AND RECYCLABLE CATALYST

Sujit S. Mathakari*

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Abstract

In the present research work, we have evaluated the catalytic efficiency of silica supported methane sulfonic acid for the synthesis of benzodiazepine derivatives through the cyclisation of 2- aminothiophenol with aliphatic/aryl and heteroaryl methyl ketones. The reported protocol is highly efficient in attendance of 0.5 g silica supported methane sulfonic acid as a heterogeneous catalyst in 10 mL CH3CN solvent under reflux condition. Use of non-corrosive, nontoxic and efficient catalyst at ambient temperature are the key advantages of reported method and it comes with certain additional compensations like shorter reaction time, simple work-up technique, high yields, recyclability of catalyst and easy availability.

Keywords: SiO2@MSA; Benzodiazopines; Heterogeneous catalyst; Recyclable catalyst, Efficient protocol.