Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF ALBENDAZOLE BY USING A CO-CRYSTAL TECHNIQUE

Shaik Shabbeer*, B. Pallavi, V. Gayathri, M. Swathi and K.N.V. Rao

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Abstract

Background: Albendazole is used as an anthelminthic. It is a BCS class II drug having poor aqueous solubility. Objective: This study was aimed to formulate and evaluate fast-dissolving tablets of containing co-crystals of Albendazole for the improvisation of critical attributes of the product such as dissolution rates, solubility and oral bioavailability. Methods: Co-crystals were prepared by Solvent Evaporation method using Natural gums such as Xanthan gum as coformers. Tablets were compressed by using direct compression method using SSG and Crospovidone as super disintegrants in different concentration. Results: Pre-formulation studies were performed and evaluation of prepared co-crystals revealed that Co-crystals formulated with Xanthan gum showed best results. The manufactured fastdissolving tablets were evaluated for different parameters including weight variation, hardness, thickness, friability, drug content, In-vitro disintegration and In-vitro dissolution studies. Formulation F4 shows significant change in dissolution rate and also helped to increase the solubility of poorly water- soluble drugs and both of them i.e. solubility and percentage of drug release are the key factors to exhibit the efficiency of the drug. Formulation of co-crystal with Xanthan gum in 1:1 ratio showed highest drug content (99%) using Crospovidone. Conclusion: According to the result obtained, fast-dissolving tablet containing co-crystals of albendazole enhances the dissolution rate, solubility and hence increases the therapeutic efficacy and could be considered convenient oral delivery systems to enhance the drug bioavailability.

Keywords: Albendazole, co-crystal, co-former.