Abstract

ONE POT SYNTHESIS 7, 7-DIMETHYL-4-PHENYL-2-THIOXO-2, 3,4,6,7, 8- HEXAHYDRO-1H-QUINAZOLIN-5-ONES PROMOTED BY ZROCL2 AND STUDY OF BIOEVLUATION

M. Ramesh and Krishnarao*

Abstract

A simple and an efficient method for the Synthesis of derivatives 7, 7- dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 7, 8-hexahydro-1H-quinazolin- 5-one from dimedone and substituted aromatic aldehydes with thiourea in the presence of ZrOCl2 catalyst and an excellent yields under reflux through condensation followed by cyclization of the desired products. All structures of derivatives were confirmed by 1H NMR and 13C NMR spectroscopy. In addition to study of the Bioevluation of desired compounds.

Keywords: Dimedone, substitutedaryialdehydes, 7, 7-Dimethyl-4- phenyl-2-thioxo-1, 2, 3, 4, 6, 7, 8-hexahydro-1H-quinazolin-5-ones, ZrOCl2, Bioevluation.