Abstract

AN EFFICIENT BIOACTIVE SYNTHESIS OF NOVEL 1-(2-METHYL-1, 5-DIPHENYL-1H-PYRROL-3-YL) ETHANONE DERIVATIVES PROMOTED BY DBU

Gavaraganesh and Krishnarao*

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Abstract

In this study of work, an attempt to find new class antibacterial agent of series 1-(2-methyl-1,5-diphenyl-1H-pyrrol-3-yl)ethanone(4a–4j) were success fully synthesized from phenacyl bromide, substituted aryl amine and Aetylacetone in the presence of organic base such as DBU promoted in ethanol under reflux. The synthesized compounds were evaluated by spectroscopic techniques such as 1HNMR, 13CNMR and LCMS and elemental analysis. In additionally newly synthesized derivatives were evaluated for their antibacterial activity.

Keywords: Phenacyl Bromide; Aetylacetone; substituted aryl amines; D B U; 1-(2-methyl-1, 5-diphenyl-1H-pyrrol-3-yl) ethanone. Antimicrobial activity.