Abstract

CANCER METABOLIC PROGRAMMING & INNOVATIVE APPROACH TO OVERCOMES RESISTANCE AND TOXICITY OF ANTI-CANCER DRUG

*Miss. Gauravi N. Gawali, Mr. Dhiraj Y. Kapadnis, Miss. Kaveri S. Sonawane,Mr. Gitesh D. Pagare, Miss. Mahima B. Sable, Miss. Maheshwari N. Jadhav, Miss. Ankita P. Pagare, Miss. Darshana M. Patil

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Abstract

Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg‟s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients. Every year, cancer is responsible for millions of deaths worldwide and, even though much progress Has been achieved in medicine, there are still many issues that must be addressed in order to Improve cancer therapy. For this reason, oncological research is putting a lot of effort towards finding New and efficient therapies which can alleviate critical side effects caused by conventional Treatments. Different technologies are currently under evaluation in clinical trials or have been Already introduced into clinical practice. While nanomedicine is contributing to the development of Biocompatible materials both for diagnostic and therapeutic purposes, bioengineering of Extracellular vesicles and cells derived from patients has allowed designing ad hoc systems and Univocal targeting strategies. In this review, we will provide an indepth analysis of the most Innovative advances in basic and applied cancer research.

Keywords: Cell cycle, energy metabolism, glycolysis, glutaminolysis, mitochondria cancer, nanomedicine, extracellular vesicles, targeted therapy, immunotherapy, gene Therapy, thermal ablation, radiomics, pathomics.