Abstract

DEIGNED SYNTHESIS OF N-(5-(4-METHOXYPHENYL) THIAZOL-2- YL) BENZAMIDE ANALGUEOUS PROMOTED BY DCC

D. Jagadeesh and N. Krishnarao*

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Abstract

An efficient and convenient procedure has been described for N-(5-(4- methoxyphenyl) thiazol-2-yl) benzamide analgueous that can be obtained from the reaction of 5-(4-methoxyphenyl) thiophen-2-amine and substituted aromatic carbonyl halides in the presence of CDI /Et3N as solvent at reflux. 5-(4-methoxyphenyl) thiophen-2-amine can be obtained from2-bromo-1-(4-methoxyphenyl) ethan-1-one with thiourea in the presence of sodium acetate and acetic acid at 700C. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR and LCMS) and the structural determination was evaluated by elemental analysis. Besides to this, all the newly synthesized compounds were examined for their antibacterial activities and antifungal activity by disc diffusion method against the organism of Aspergillus Niger and Candida albicans.

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