Abstract

AN EFFICIENT SYNTHESIS OF N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AND ANTIMICROBIAL ACTIVITY

Kilari Janardhan Rao* and Dr. N. Krishnarao

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Abstract

Heterocycles, which are molecules with scaffolds of benzimidazoles, are very significant and interesting since they belong to a large class of synthetic compounds with advantageous biological characteristics. The synthesis of novel N-substituted benzimidazoles derivatives (5a–5f) is presented in this article. The process of creating these compounds began with the design of the N-substituted benzimidazoles (5a-f). With methane sulfonic acid acting as a catalyst, O-phenylene diamine and pchlorobenaldehyde underwent a condensation process that produced the derivative 3a. All of the compounds were assessed using sophisticated spectroscopic data (1H NMR, 13C NMR, and LCMS), and elemental analysis was used to compute the structural determination of the unique derivations. Ten hybridized acridine derivatives were created in this study by cyclocondensation, and there in vitro antifungal properties were assessed. Antimicrobial activity.

Keywords: O-phenyldiamine, 4-Chlorobenzaldehyde, methanesufonicacid, substituted(bromomethyl) benzene, 1-benzyl-2-(4-chlorophenyl)-1H-benzo[d]imidazole, Antifungal Activity.