Abstract

REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM

Yogesh Kumar Kaushal*, Mansi Sharma, Piyush Kashyap and Dr. Ravinesh Mishra

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Abstract

Transdermal drug delivery devices are used to provide medications topically. Transdermal patches are pharmaceutical preparations of varied sizes that include one or more active ingredients and are meant to be placed to unbroken skin in order to pass through the skin barriers to transport the active ingredient to the systemic circulation, therefore avoiding the first pass effect. A transdermal drug delivery system has an advantage over other types of medication delivery such as oral, topical, intravenous, intramuscular, and so on because the patch offers a controlled release of the medication into the patient. In TDDS drug is placed within the patch, and the patch is worn on the skin for a long time. This method ensures that the drug remains in the circulation for an extended period of time due to its steady concentration. The primary components of TDDS are a polymer matrix, drugs, plasticizer and permeation enhancers. Polymers include HPMC, carbopol, methylcellulose, gum Arabic, starch, shellac, and synthetics such as acetyl copolymer, polyvinyl chloride, polyamide, and polyvinyl acetate. TDDS have different types of system which includes single layer drug in adhesive, multilayer drug in adhesive, matrix, reservoir and Vapour Patch. There are several factors that affect TDDS such as physico-chemical Factors, biological and environmental factors. Transdermal drug delivery is a relatively new technology with great potential to reduce the usage of needles for administering various drugs; however, the cost is also a factor that needs to be considered, especially in developing countries like India, which have the largest populations worldwide. Because TDDS are more expensive, they are a hidden aspect of therapy that must be used in. An overview of TDDS, including its benefits and drawbacks, essential components, types, and evaluation, is provided in the review article

Keywords: Transdermal drug delivery system (TDDS), Transport mechanism, Permeability, Skin, Permeation mechanism, Iontophoresis, Microneedles.