Abstract

MICROEMULSION FORMULATION AND SCALEUP STUDIES FOR TOPICAL APPLICATION

Mansi Sharma*, Vishal Thakur, Dr. Akriti Singh, Vishal Sharma, Vikas Palsra

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Abstract

A microemulsion is thermodynamically stable of two immiscible liquids consisting of the microdomain of one or both liquids stabilized surfactant molecules. The microemulsion is a novel drug delivery system that increases the bioavailability in a biological system. Various screening/optimization studies were carried out to determine several factors that can improve the penetration and deposition of microemulsions in the skin layers. The microemulsion is a mixture of liquid oil, surfactant, and water in an aqueous phase that may contain water-soluble surfactants and co-surfactants which stabilize the system. The oil phase accommodates the lipid-soluble drugs and excipients which are dissolved before the preparation of microemulsion. Microemulsions serve as a delivery system to deliver drugs that allow improved transportation across the subcutaneous (SC) layer of the epidermal skin. This paper has reviewed to investigate current improvements experienced in the field of microemulsions as an important vehicle to transport drugs topically. Further, the scale-up study has to be incorporated in which pharmaceutical product development occurs until it reaches to market. Pilot plant studies of topical microemulsion will be enhanced the quality of the final product and enhance the shelf life of the microemulsion by improving critical material parameters and critical process parameters.

Keywords: Microemulsions; Topical drug delivery; Bioavailability; Pilot Scale-up;Optimization.