Abstract

ADVANCEMENTS IN PULSATILE DRUG DELIVERY SYSTEMS: A REVIEW

P. Deepan*, Bharathi M., Kannabirran Vaikumdam, Senthilkumar K. and Rajalingam D.

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Abstract

Oral pulsatile drug delivery systems (PDDS) offer a promising approach to chronotherapeutic goals, particularly for managing chronic diseases with nocturnal symptoms. By incorporating programmable lag phases before rapid drug release, PDDS enhance therapeutic efficacy. Synchronized with the body's circadian rhythm, they hold potential in treating conditions like asthma, cardiovascular diseases, arthritis, and hypercholesterolemia. Overcoming challenges such as gastric emptying, PDDS enable time-based colonic release, augmenting their benefits. These systems ensure precise drug delivery, independent of environmental factors, across various therapeutic applications. Marketed technologies like PulsincapTM and Diffucaps provide tailored drug release profiles for diseases such as asthma and peptic ulcers. Pulsatile drug delivery systems promise to transform therapy paradigms, improving patient outcomes and treatment adherence.

Keywords: Pulsatile Drug delivery systems, Therapeutic application, Circadian rhythms, Chronic diseases, Chronopharmaceutics.