Abstract

DESIGN, SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTI DIABETIC ACTIVITY STUDIES ON SEMISYNTHETIC DERIVATIVES OF CURCUMIN

*S. Banupriya and G. Sathya Pooja

Abstract

The present work has been under taken to synthesis curcumin derivatives. The synthesized compounds were characterised by UV and IR spectroscopy and screened for in vitro alpha-amylase inhibitory activity. The semisynthetic derivatives of curcumin was prepared using two schemes to synthesize pyrazole and pyrimidine derivatives. Pyrazole derivative were prepared by condensation of curcumin with hydrazine hydrate, pyrimidine derivative were prepared by condensation of curcumin with urea. The structure of the compounds synthesized during the present work were established on the basis of the chemical data, IR, UV data. The purity of the compounds were established by single spot-on TLC plates. The newly synthesized compounds were evaluated for their α- amylase inhibitory activity.

Keywords: Curcumin, alpha amylase, Pyrazole, Pyrimidine, Semisynthetic.