Abstract

IN-VITRO ASSAYS TO INVESTIGATE ANTI-INFLAMMATORY, ANTI-DIABETIC AND ANTI- MICROBIAL ACTIVITY OF HERBAL EXTRACT OF ARISTOLOCHIA INDICA- A REVIEW

Neethu R.*, Tanishka Tandel, Niyatee Thakur, Aamir Ahmad, Ruchi Borkar and Dr. Rupesh Pingle

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Abstract

Aristolochia, a diverse genus within the Aristolochiaceae family, boasts over 400 perennial species. Traditionally, various Aristolochia plants have been used in herbal remedies for snakebites, wounds, and tumors, with some applications persisting, especially in Chinese medicine. Locally known as Isharmul, this endangered medicinal plant, characterized by its unique long, twining stems, grows in the plains and low hills spanning Nepal's lower Bengal to Bangladesh's Chittagong and India's Coromandal Coast. Aristolochia indica Linn, part of the Aristolochiaceae family, was traditionally utilized in indigenous medicine to treat skin ailments, inflammation, and as a purgative. It possesses antimicrobial, antioxidant, antibacterial, antiinflammatory, immunomodulatory, anticancer, antidiabetic, and antivenom properties Studies have been interested in the Aristolochia indica had revealed that the methanolic extract from the plant contains number of phenols and flavonoids. So, the Aristolochia indica is rich source of nature which can be accounted for traditional uses as antioxidant the aristolochic acid is the main chemical complex of the plant. This acid contributes carcinogenic and genotoxic property and other effects of the plant. Aristolochia indica is a rich natural source due to its traditional use as aristolochic acid. The chemical component of the plant acts as a classic defense mechanism against various infections, as the antioxidant aristolochic acid is the exclusive chemical constituent of the plant. Aristolochia indica has traditionally been used to treat various conditions, including respiratory diseases, gastrointestinal diseases, and skin infections.

Keywords: Aristolochic Acid, Protein Denaturation Assay, Alpha Amylase, Agar Well.