Abstract

AN UPDATED REVIEW ON NANOVESICLES - ETHOSOMES, AS A NOVEL DRUG DELIVERY SYSTEM

Yogita Chunchuwar–Mandlik*, Dr. Rahul H. Kasliwal, Dr. Yogesh N. Gholse and Dr. Dinesh R. Chaple

Abstract

Nanoparticles have various potential applications in drug delivery, clinical medicine, research, and other sciences, making them a promising technology in the field of nanotechnology. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. Ethosomes are an improved version of liposomes commonly used to transport drugs. Ethosomal vesicles are structurally composed of a phospholipid bilayer and an inner aqueous core containing drugs. Ethosomes can range in size from tens of nanometers to microns, and is influenced by the composition of the formulation. The concentration of phospholipid and ethanol affect the size of ethosomes. Because of their unique structure, ethosomes can encapsulate and deliver through the skin highly lipophilic molecules. Ethosomes are innovative carriers that meet the essential criteria for efficient and safe lipophilic or hydrophilic drug administration One of the unique properties of ethosomes is their ability to efficiently encapsulate molecules with different physicochemical characteristics. For enhanced application convenience and improved stability, ethosomal dispersions can be incorporated into creams, patches, and gels. The lack of toxicity, good stability, and ease of manufacturing make ethosomal carriers a valuable tool for efficient dermal application. Another benefit of these new therapies is they could reduce treatment costs. Ethosomes can efficiently deliver challenging biotechnological agents through the skin and cellular membranes. Using these carriers, new noninvasive therapies could be designed to meet unmet needs. These include improved treatments of deep skin microbial, viral infections, skin cancers, and new antirheumatic products.

Keywords: Vesicles, Transdermal, Ethanol, Ethosomes, penetration, carrier.