Abstract

DEVELOPMENT AND CHARACTERIZATION OF PH-DEPEND MESOPOROUS SILICA NANOPARTICLES LOADED WITH PACRITINIB CITRATE FOR COLON-TARGETED DRUG DELIVERY USING NON IONIC SURFACTANT

S. K. Kanungo, Udai Chand Agrahari*, S. K. Panda, S. K. Pattanaik and A. Ali

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Abstract

This study presents the fabrication, characterization, and optimization of pH-dependent mesoporous silica nanoparticles (MSNs) loaded with Pacritinib citrate for colon-targeted drug delivery. A 32 factorial design was employed to evaluate different formulations based on the ratio of Eudragit S100 and L100 polymers (A) and phosphatidylcholine content (B). The responses, including entrapment efficiency, drug release at 4 hours, and drug release at 8 hours, were investigated to optimize the formulation. The FTIR analysis confirmed the successful encapsulation of Pacritinib citrate within the MSNs with increase concentration of polysorbate80up to 5%. Furthermore, in vitro release studies revealed sustained drug release profiles, indicating the potential for colon-specific drug delivery. Pharmacokinetic studies demonstrated enhanced bioavailability of Pacritinib citrate nanoparticles compared to pure drug micro suspension. The optimized formulation exhibited desirable stability and pH-dependent drug release behaviour, making it a promising candidate for the treatment of colonic diseases.

Keywords: Mesoporous silica nanoparticles, Pacritinib citrate, Colon-targeted drug delivery, Factorial design, FTIR analysis, in vitro release, Pharmacokinetics.