Abstract

COMPARATIVE STUDIES OF ANTIGASTRIC AND ANTIULCER ACTIVITIES AMONG THE THREE HERBAL PLANTS WITH RABEPRAZOLE IN SHAY RATS

S. K. Pattanaik, Udai Chand Agrahari*, S. K. Panda and S. K. Kanungo

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Abstract

A peptic ulcer is an erosion in a segment of the gastro intestinal mucosa, typically in the stomach (Gastric ulcer) or first few centi meters of duodenum (Duodenal ulcer) that penetrates through the muscularis mucosae. Contrary to popular belief, ulcer is not caused by spicy food but instead is most commonly due to either an infection or long-term use of medications. Standard treatment is a combination of drugs including antibiotics and a proton pump inhibitor. Literature suggests that number of synthetic drugs are used in the management of peptic ulcers but elicit several adverse effects. Therefore, Indian herbal plants stand out as being exceptional for its ethnic, ethnobotanical and ethno-pharmaceutical use. In this review attempts have been made to know about some plants which may be used in treatment or prevention of peptic ulcers and a comparative study among each other with the standard drug Rabeprazole, such plants like Abutilon indicum, Elephantopus scaber and Millettia Peguensis proved active in antiulcer therapy. Different extracts of Abutilon indicum, Elephantopus scaber and Millettia peguensis plants were tested for its antigastric and antiulcer activity in shay rat model, out of which the alcoholic extract of the plants afforded more effective antiulcer activity and shows complete inhibition of ulceration which are comparable to the antiulcer activity shown by 2mg/kg of Rabeprazole in shay rat.

Keywords: Antiulcer activity, Herbal plants, Shay.